Rabbit Anti-PNKP Polyclonal Antibody
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产品编号
PAV3095
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别名
polynucleotide kinase 3'-phosphatase, AOA4, CMT2B2, EIEE10, MCSZ, PNK
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | polynucleotide kinase 3'-phosphatase, AOA4, CMT2B2, EIEE10, MCSZ, PNK |
| Catalog Number | PAV3095 |
| Product Description | Rabbit polyclonal antibody raised against human PNKP (Bifunctional polynucleotide phosphatase/kinase). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PNKP |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010] |
| Immunogen | This antibody was raised against from part region of human PNKP protein (UniProt: Q96T60) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 11284 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈57.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 57.1 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q96T60 |
| Note | Gene ID: 11284; UniProt: Q96T60; Chromosome: 19q13.33; Predicted MW: 57.1 kDa |
| Function | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PNKP Polyclonal Antibody |
| Target | PNKP |
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