Rabbit Anti-PI3R6/PIK3R6 Polyclonal Antibody
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产品编号
PAV3031
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别名
phosphoinositide-3-kinase regulatory subunit 6, C17orf38, HsT41028, p84 PIKAP, p87(PIKAP), p87PIKAP
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | phosphoinositide-3-kinase regulatory subunit 6, C17orf38, HsT41028, p84 PIKAP, p87(PIKAP), p87PIKAP |
| Catalog Number | PAV3031 |
| Product Description | Rabbit polyclonal antibody raised against human PIK3R6 (Phosphoinositide 3-kinase regulatory subunit 6). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PIK3R6 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| Immunogen | This antibody was raised against from part region of human PIK3R6 protein (UniProt: Q5UE93) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 146850 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈84.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 84.3 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q5UE93 |
| Note | Gene ID: 146850; UniProt: Q5UE93; Chromosome: 17p13.1; Predicted MW: 84.3 kDa |
| Function | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PIK3R6 Polyclonal Antibody |
| Target | PIK3R6 |
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