Rabbit Anti-NEK3 Polyclonal Antibody
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产品编号
PAV2500
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别名
NIMA related kinase 3, HSPK36
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | NIMA related kinase 3, HSPK36 |
| Catalog Number | PAV2500 |
| Product Description | Rabbit polyclonal antibody raised against human NEK3 (Serine/threonine-protein kinase Nek3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NEK3 |
| Species | Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon. [provided by RefSeq, Sep 2019] |
| Immunogen | This antibody was raised against from part region of human NEK3 protein (UniProt: P51956) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 4752 |
| Tag | Unconjugated |
| Cross-reactivity | Mouse |
| Predicted Molecular Weight | ≈57.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 57.7 kDa |
| Cross-reactivity | Mouse |
| Uniprot ID | P51956 |
| Note | Gene ID: 4752; UniProt: P51956; Chromosome: 13q14.3; Predicted MW: 57.7 kDa |
| Function | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NEK3 Polyclonal Antibody |
| Target | NEK3 |
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