Rabbit Anti-MK12/MAPK12 Polyclonal Antibody
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产品编号
PAV2316
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别名
mitogen-activated protein kinase 12, ERK-6, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | mitogen-activated protein kinase 12, ERK-6, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3 |
| Catalog Number | PAV2316 |
| Product Description | Rabbit polyclonal antibody raised against human MAPK12 (Mitogen-activated protein kinase 12). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MAPK12 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human MAPK12 protein (UniProt: P53778) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6300 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈41.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 41.9 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P53778 |
| Note | Gene ID: 6300; UniProt: P53778; Chromosome: 22q13.33; Predicted MW: 41.9 kDa |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MAPK12 Polyclonal Antibody |
| Target | MAPK12 |
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