Rabbit Anti-PREP Polyclonal Antibody

产品编号

PAV3152

别名

prolyl endopeptidase, PE, PEP

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	prolyl endopeptidase, PE, PEP
Catalog Number	PAV3152
Product Description	Rabbit polyclonal antibody raised against human PREP (Presequence protease, mitochondrial). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	PREP
Species	Human, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	蛋白酶
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
Immunogen	This antibody was raised against from part region of human PREP protein (UniProt: Q5JRX3)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	5550
Tag	Unconjugated
Cross-reactivity	Human, Mouse
Predicted Molecular Weight	≈117.4 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	117.4 kDa
Cross-reactivity	Human, Mouse
Uniprot ID	Q5JRX3
Note	Gene ID: 5550; UniProt: Q5JRX3; Chromosome: 6q21; Predicted MW: 117.4 kDa
Function	Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human PREP Polyclonal Antibody
Target	PREP