Rabbit Anti-PAPP1/PAPPA Polyclonal Antibody
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产品编号
PAV2925
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别名
pappalysin 1, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | pappalysin 1, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1 |
| Catalog Number | PAV2925 |
| Product Description | Rabbit polyclonal antibody raised against human PAPPA (Pappalysin-1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PAPPA |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017] |
| Immunogen | This antibody was raised against from part region of human PAPPA protein (UniProt: Q13219) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 5069 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈181.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 181.0 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q13219 |
| Note | Gene ID: 5069; UniProt: Q13219; Chromosome: 9q33.1; Predicted MW: 181.0 kDa |
| Function | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PAPPA Polyclonal Antibody |
| Target | PAPPA |
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