Rabbit Anti-SPRE1/SPRED1 Polyclonal Antibody
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产品编号
PAV3795
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别名
sprouty related EVH1 domain containing 1, LGSS, NFLS, PPP1R147, hSpred1, spred-1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sprouty related EVH1 domain containing 1, LGSS, NFLS, PPP1R147, hSpred1, spred-1 |
| Catalog Number | PAV3795 |
| Product Description | Rabbit polyclonal antibody raised against human SPRED1 (Sprouty-related, EVH1 domain-containing protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SPRED1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 磷酸酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human SPRED1 protein (UniProt: Q7Z699) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 161742 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈50.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 50.5 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q7Z699 |
| Note | Gene ID: 161742; UniProt: Q7Z699; Chromosome: 15q14; Predicted MW: 50.5 kDa |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SPRED1 Polyclonal Antibody |
| Target | SPRED1 |
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