Rabbit Anti-PPAC2/PLPP6 Polyclonal Antibody
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产品编号
PAV3124
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别名
phospholipid phosphatase 6, LPRP-B, PA-PSP, PDP1, PPAPDC2, PSDP, bA6J24.6
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | phospholipid phosphatase 6, LPRP-B, PA-PSP, PDP1, PPAPDC2, PSDP, bA6J24.6 |
| Catalog Number | PAV3124 |
| Product Description | Rabbit polyclonal antibody raised against human PLPP6 (Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PLPP6 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 磷酸酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables isoprenoid diphosphate phosphatase activity and phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Located in endoplasmic reticulum membrane and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human PLPP6 protein (UniProt: Q8IY26) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 403313 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈32.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 32.2 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q8IY26 |
| Note | Gene ID: 403313; UniProt: Q8IY26; Chromosome: 9p24.1; Predicted MW: 32.2 kDa |
| Function | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PLPP6 Polyclonal Antibody |
| Target | PLPP6 |
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