Rabbit Anti-PP2BB/PPP3CB Polyclonal Antibody

产品编号

PAV3120

别名

protein phosphatase 3 catalytic subunit beta, CALNA2, CALNB, CNA2, PP2Bbeta

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	protein phosphatase 3 catalytic subunit beta, CALNA2, CALNB, CNA2, PP2Bbeta
Catalog Number	PAV3120
Product Description	Rabbit polyclonal antibody raised against human PPP3CB (Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	PPP3CB
Species	Human, Rat, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	磷酸酶
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of lysosome organization; and positive regulation of protein localization to nucleus. Located in cytosol. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Jun 2026]
Immunogen	This antibody was raised against from part region of human PPP3CB protein (UniProt: P16298)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	5532
Tag	Unconjugated
Cross-reactivity	Human, Rat, Mouse
Predicted Molecular Weight	≈59.0 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	59.0 kDa
Cross-reactivity	Human, Rat, Mouse
Uniprot ID	P16298
Note	Gene ID: 5532; UniProt: P16298; Chromosome: 10q22.2; Predicted MW: 59.0 kDa
Function	Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity).
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human PPP3CB Polyclonal Antibody
Target	PPP3CB