Rabbit Anti-SIGIR/SIGIRR Polyclonal Antibody
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产品编号
PAV3680
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别名
single Ig and TIR domain containing, IL-1R8, TIR8
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | single Ig and TIR domain containing, IL-1R8, TIR8 |
| Catalog Number | PAV3680 |
| Product Description | Rabbit polyclonal antibody raised against human SIGIRR (Single Ig IL-1-related receptor). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SIGIRR |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 模式识别受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human SIGIRR protein (UniProt: Q6IA17) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 59307 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈45.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 45.7 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | Q6IA17 |
| Note | Gene ID: 59307; UniProt: Q6IA17; Chromosome: 11p15.5; Predicted MW: 45.7 kDa |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SIGIRR Polyclonal Antibody |
| Target | SIGIRR |
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