Rabbit Anti-SARM1 Polyclonal Antibody
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产品编号
PAV3575
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别名
sterile alpha and TIR motif containing 1, HsTIR, MyD88-5, SAMD2, SARM, hSARM1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sterile alpha and TIR motif containing 1, HsTIR, MyD88-5, SAMD2, SARM, hSARM1 |
| Catalog Number | PAV3575 |
| Product Description | Rabbit polyclonal antibody raised against human SARM1 (NAD hydrolase SARM1 hydrolase SARM1)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SARM1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 模式识别受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables double-stranded DNA binding activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and identical protein binding activity. Involved in NAD+ catabolic process; positive regulation of programmed cell death; and response to axon injury. Located in cytoplasm. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human SARM1 protein (UniProt: Q6SZW1) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 23098 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈79.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 79.4 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q6SZW1 |
| Note | Gene ID: 23098; UniProt: Q6SZW1; Chromosome: 17q11.2; Predicted MW: 79.4 kDa |
| Function | NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SARM1 Polyclonal Antibody |
| Target | SARM1 |
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