Rabbit Anti-TMX1 Polyclonal Antibody
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产品编号
PAV4078
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别名
thioredoxin related transmembrane protein 1, PDIA11, TMX, TXNDC, TXNDC1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | thioredoxin related transmembrane protein 1, PDIA11, TMX, TXNDC, TXNDC1 |
| Catalog Number | PAV4078 |
| Product Description | Rabbit polyclonal antibody raised against human TMX1 (Thioredoxin-related transmembrane protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TMX1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 氧化还原酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017] |
| Immunogen | This antibody was raised against from part region of human TMX1 protein (UniProt: Q9H3N1) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 81542 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈31.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 31.8 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9H3N1 |
| Note | Gene ID: 81542; UniProt: Q9H3N1; Chromosome: 14q22.1; Predicted MW: 31.8 kDa |
| Function | Thioredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TMX1 Polyclonal Antibody |
| Target | TMX1 |
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