Rabbit Anti-PGDH/HPGD Polyclonal Antibody
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产品编号
PAV3008
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别名
15-hydroxyprostaglandin dehydrogenase, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | 15-hydroxyprostaglandin dehydrogenase, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1 |
| Catalog Number | PAV3008 |
| Product Description | Rabbit polyclonal antibody raised against human HPGD (15-hydroxyprostaglandin dehydrogenase])). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | HPGD |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 氧化还原酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| Immunogen | This antibody was raised against from part region of human HPGD protein (UniProt: P15428) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 3248 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈29.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 29.0 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P15428 |
| Note | Gene ID: 3248; UniProt: P15428; Chromosome: 4q34.1; Predicted MW: 29.0 kDa |
| Function | Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human HPGD Polyclonal Antibody |
| Target | HPGD |
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