Rabbit Anti-RANB3/RANBP3 Polyclonal Antibody
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产品编号
PAV3268
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别名
RAN binding protein 3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | RAN binding protein 3 |
| Catalog Number | PAV3268 |
| Product Description | Rabbit polyclonal antibody raised against human RANBP3 (Ran-binding protein 3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RANBP3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他结构蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human RANBP3 protein (UniProt: Q9H6Z4) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 8498 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈60.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 60.2 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9H6Z4 |
| Note | Gene ID: 8498; UniProt: Q9H6Z4; Chromosome: 19p13.3; Predicted MW: 60.2 kDa |
| Function | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RANBP3 Polyclonal Antibody |
| Target | RANBP3 |
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