Rabbit Anti-PTPRH Polyclonal Antibody
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产品编号
PAV3213
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别名
protein tyrosine phosphatase receptor type H, R-PTP-H, SAP1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | protein tyrosine phosphatase receptor type H, R-PTP-H, SAP1 |
| Catalog Number | PAV3213 |
| Product Description | Rabbit polyclonal antibody raised against human PTPRH (Receptor-type tyrosine-protein phosphatase H). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PTPRH |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] |
| Immunogen | This antibody was raised against from part region of human PTPRH protein (UniProt: Q9HD43) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 5794 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈122.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 122.4 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q9HD43 |
| Note | Gene ID: 5794; UniProt: Q9HD43; Chromosome: 19q13.42; Predicted MW: 122.4 kDa |
| Function | Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PTPRH Polyclonal Antibody |
| Target | PTPRH |
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