Rabbit Anti-NPSR1 Polyclonal Antibody
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产品编号
PAV2577
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别名
neuropeptide S receptor 1, ASRT2, FNSS3, GPR154, GPRA, NPSR, PGR14, VRR1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | neuropeptide S receptor 1, ASRT2, FNSS3, GPR154, GPRA, NPSR, PGR14, VRR1 |
| Catalog Number | PAV2577 |
| Product Description | Rabbit polyclonal antibody raised against human NPSR1 (Neuropeptide S receptor). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NPSR1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| Immunogen | This antibody was raised against from part region of human NPSR1 protein (UniProt: Q6W5P4) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 387129 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈42.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 42.7 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q6W5P4 |
| Note | Gene ID: 387129; UniProt: Q6W5P4; Chromosome: 7p14.3; Predicted MW: 42.7 kDa |
| Function | G protein-coupled receptor for neuropeptide S (NPS). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NPSR1 Polyclonal Antibody |
| Target | NPSR1 |
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