Rabbit Anti-STAB2 Polyclonal Antibody
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产品编号
PAV3841
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别名
stabilin 2, FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | stabilin 2, FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1 |
| Catalog Number | PAV3841 |
| Product Description | Rabbit polyclonal antibody raised against human STAB2 (Stabilin-2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: IHC-p. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | STAB2 |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他免疫分子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human STAB2 protein (UniProt: Q8WWQ8) |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-200 |
| Gene ID | 55576 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈277.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 277.0 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | Q8WWQ8 |
| Note | Gene ID: 55576; UniProt: Q8WWQ8; Chromosome: 12q23.3; Predicted MW: 277.0 kDa |
| Function | Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human STAB2 Polyclonal Antibody |
| Target | STAB2 |
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