Rabbit Anti-STP1/SULT1A1 Polyclonal Antibody
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产品编号
PAV3860
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别名
sulfotransferase family 1A member 1, HAST1/HAST2, P-PST, P-PST 1, PST, ST1A1, ST1A3, STP, STP1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sulfotransferase family 1A member 1, HAST1/HAST2, P-PST, P-PST 1, PST, ST1A1, ST1A3, STP, STP1 |
| Catalog Number | PAV3860 |
| Product Description | Rabbit polyclonal antibody raised against human SULT1A1 (Sulfotransferase 1A1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: IHC-p. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SULT1A1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human SULT1A1 protein (UniProt: P50225) |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-200 |
| Gene ID | 6817 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈34.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 34.2 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P50225 |
| Note | Gene ID: 6817; UniProt: P50225; Chromosome: 16p11.2; Predicted MW: 34.2 kDa |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SULT1A1 Polyclonal Antibody |
| Target | SULT1A1 |
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