Rabbit Anti-SPTC2/SPTLC2 Polyclonal Antibody

产品编号

PAV3805

别名

serine palmitoyltransferase long chain base subunit 2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

立即询价加入询价列表大包装定制

产品介绍

Alias	serine palmitoyltransferase long chain base subunit 2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a
Catalog Number	PAV3805
Product Description	Rabbit polyclonal antibody raised against human SPTLC2 (Serine palmitoyltransferase 2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	SPTLC2
Species	Human, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	代谢酶
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]
Immunogen	This antibody was raised against from part region of human SPTLC2 protein (UniProt: O15270)
Application	WB
Recommended Dilution	WB 1:500-2000
Gene ID	9517
Tag	Unconjugated
Cross-reactivity	Human, Mouse
Predicted Molecular Weight	≈62.9 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	62.9 kDa
Cross-reactivity	Human, Mouse
Uniprot ID	O15270
Note	Gene ID: 9517; UniProt: O15270; Chromosome: 14q24.3; Predicted MW: 62.9 kDa
Function	Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Crucial for adipogenesis (By similarity).
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human SPTLC2 Polyclonal Antibody
Target	SPTLC2