Rabbit Anti-SPS1/SEPHS1 Polyclonal Antibody
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产品编号
PAV3799
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别名
selenophosphate synthetase 1, SELD, SPS, SPS1, VERBRAS2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | selenophosphate synthetase 1, SELD, SPS, SPS1, VERBRAS2 |
| Catalog Number | PAV3799 |
| Product Description | Rabbit polyclonal antibody raised against human SEPHS1 (Zincore component SEPHS1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SEPHS1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010] |
| Immunogen | This antibody was raised against from part region of human SEPHS1 protein (UniProt: P49903) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 22929 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈42.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 42.9 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | P49903 |
| Note | Gene ID: 22929; UniProt: P49903; Chromosome: 10p13; Predicted MW: 42.9 kDa |
| Function | Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role. Required for cardiac differentiation (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SEPHS1 Polyclonal Antibody |
| Target | SEPHS1 |
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