Rabbit Anti-SGPP1 Polyclonal Antibody
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产品编号
PAV3653
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别名
sphingosine-1-phosphate phosphatase 1, SPP-1, SPPase1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sphingosine-1-phosphate phosphatase 1, SPP-1, SPPase1 |
| Catalog Number | PAV3653 |
| Product Description | Rabbit polyclonal antibody raised against human SGPP1 (Sphingosine-1-phosphate phosphatase 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SGPP1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009] |
| Immunogen | This antibody was raised against from part region of human SGPP1 protein (UniProt: Q9BX95) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 81537 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈49.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 49.1 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q9BX95 |
| Note | Gene ID: 81537; UniProt: Q9BX95; Chromosome: 14q23.2; Predicted MW: 49.1 kDa |
| Function | Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger. Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SGPP1 Polyclonal Antibody |
| Target | SGPP1 |
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