Rabbit Anti-SFTA1/SFTPA1 Polyclonal Antibody
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产品编号
PAV3641
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别名
surfactant protein A1, COLEC4, ILD1, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | surfactant protein A1, COLEC4, ILD1, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1 |
| Catalog Number | PAV3641 |
| Product Description | Rabbit polyclonal antibody raised against human SFTPA1 (Pulmonary surfactant-associated protein A1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SFTPA1 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| Immunogen | This antibody was raised against from part region of human SFTPA1 protein (UniProt: Q8IWL2) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 653509 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈26.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 26.2 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q8IWL2 |
| Note | Gene ID: 653509; UniProt: Q8IWL2; Chromosome: 10q22.3; Predicted MW: 26.2 kDa |
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity).; FUNCTION: (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SFTPA1 Polyclonal Antibody |
| Target | SFTPA1 |
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