Rabbit Anti-S5A1/SRD5A1 Polyclonal Antibody
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产品编号
PAV3553
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别名
steroid 5 alpha-reductase 1, S5AR 1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | steroid 5 alpha-reductase 1, S5AR 1 |
| Catalog Number | PAV3553 |
| Product Description | Rabbit polyclonal antibody raised against human SRD5A1 (3-oxo-5-alpha-steroid 4-dehydrogenase 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SRD5A1 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008] |
| Immunogen | This antibody was raised against from part region of human SRD5A1 protein (UniProt: P18405) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6715 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈29.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 29.5 kDa |
| Cross-reactivity | Human |
| Uniprot ID | P18405 |
| Note | Gene ID: 6715; UniProt: P18405; Chromosome: 5p15.31; Predicted MW: 29.5 kDa |
| Function | Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms. Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development. Besides testosterone, it can also act on other steroids, including progesterone, androstenedione, and corticoids, producing metabolites with diverse roles. Hence, it plays a central role in sexual differentiation and androgen physiology. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SRD5A1 Polyclonal Antibody |
| Target | SRD5A1 |
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