Rabbit Anti-PLCD4 Polyclonal Antibody
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产品编号
PAV3068
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别名
phospholipase C delta 4
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | phospholipase C delta 4 |
| Catalog Number | PAV3068 |
| Product Description | Rabbit polyclonal antibody raised against human PLCD4 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PLCD4 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011] |
| Immunogen | This antibody was raised against from part region of human PLCD4 protein (UniProt: Q9BRC7) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 84812 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈87.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 87.6 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q9BRC7 |
| Note | Gene ID: 84812; UniProt: Q9BRC7; Chromosome: 2q35; Predicted MW: 87.6 kDa |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.; FUNCTION: [Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PLCD4 Polyclonal Antibody |
| Target | PLCD4 |
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