Rabbit Anti-OSBP1/OSBP Polyclonal Antibody
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产品编号
PAV2866
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别名
oxysterol binding protein, OSBP1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | oxysterol binding protein, OSBP1 |
| Catalog Number | PAV2866 |
| Product Description | Rabbit polyclonal antibody raised against human OSBP (Oxysterol-binding protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | OSBP |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human OSBP protein (UniProt: P22059) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 5007 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈89.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 89.4 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | P22059 |
| Note | Gene ID: 5007; UniProt: P22059; Chromosome: 11q12.1; Predicted MW: 89.4 kDa |
| Function | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol (cholesterol) with phosphatidylinositol 4-phosphate (PI4P, 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)), delivering sterol to the Golgi in exchange for PI4P, which is subsequently degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing the stability of the relatively short lived ABCA1 protein (an important point of control for cholesterol efflux activity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human OSBP Polyclonal Antibody |
| Target | OSBP |
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