Rabbit Anti-ORML1/ORMDL1 Polyclonal Antibody
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产品编号
PAV2861
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别名
ORMDL sphingolipid biosynthesis regulator 1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | ORMDL sphingolipid biosynthesis regulator 1 |
| Catalog Number | PAV2861 |
| Product Description | Rabbit polyclonal antibody raised against human ORMDL1 (ORM1-like protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | ORMDL1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 代谢酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Involved in ceramide metabolic process. Acts upstream of or within negative regulation of ceramide biosynthetic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human ORMDL1 protein (UniProt: Q9P0S3) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 94101 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈17.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 17.4 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9P0S3 |
| Note | Gene ID: 94101; UniProt: Q9P0S3; Chromosome: 2q32.2; Predicted MW: 17.4 kDa |
| Function | Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human ORMDL1 Polyclonal Antibody |
| Target | ORMDL1 |
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