Rabbit Anti-TRPM8 Polyclonal Antibody
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产品编号
PAV4145
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别名
transient receptor potential cation channel subfamily M member 8, LTRPC6, LTrpC-6, TRPP8, trp-p8
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | transient receptor potential cation channel subfamily M member 8, LTRPC6, LTrpC-6, TRPP8, trp-p8 |
| Catalog Number | PAV4145 |
| Product Description | Rabbit polyclonal antibody raised against human TRPM8 (Transient receptor potential cation channel subfamily M member 8). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TRPM8 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; positive regulation of cold-induced thermogenesis; and thermoception. Predicted to act upstream of or within calcium ion transport; intracellular calcium ion homeostasis; and response to cold. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human TRPM8 protein (UniProt: Q7Z2W7) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 79054 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈127.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 127.7 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q7Z2W7 |
| Note | Gene ID: 79054; UniProt: Q7Z2W7; Chromosome: 2q37.1; Predicted MW: 127.7 kDa |
| Function | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures. TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel. In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TRPM8 Polyclonal Antibody |
| Target | TRPM8 |
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