Rabbit Anti-TMC2 Polyclonal Antibody
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产品编号
PAV4068
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别名
transmembrane channel like 2, C20orf145
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | transmembrane channel like 2, C20orf145 |
| Catalog Number | PAV4068 |
| Product Description | Rabbit polyclonal antibody raised against human TMC2 (Transmembrane channel-like protein 2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TMC2 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015] |
| Immunogen | This antibody was raised against from part region of human TMC2 protein (UniProt: Q8TDI7) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 117532 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈102.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 102.6 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q8TDI7 |
| Note | Gene ID: 117532; UniProt: Q8TDI7; Chromosome: 20p13; Predicted MW: 102.6 kDa |
| Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TMC2 Polyclonal Antibody |
| Target | TMC2 |
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