Rabbit Anti-TM63B/TMEM63B Polyclonal Antibody
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产品编号
PAV4065
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别名
transmembrane protein 63B, C6orf110, DEE118, LBDD, hTMEM63B
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | transmembrane protein 63B, C6orf110, DEE118, LBDD, hTMEM63B |
| Catalog Number | PAV4065 |
| Product Description | Rabbit polyclonal antibody raised against human TMEM63B (Mechanosensitive cation channel TMEM63B). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TMEM63B |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables calcium-activated cation channel activity; mechanosensitive monoatomic cation channel activity; and phospholipid scramblase activity. Predicted to be involved in several processes, including drinking behavior; intestinal stem cell homeostasis; and surfactant secretion. Located in actin cytoskeleton and bounding membrane of organelle. Is active in plasma membrane. Implicated in developmental and epileptic encephalopathy and developmental and epileptic encephalopathy 118. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human TMEM63B protein (UniProt: Q5T3F8) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 55362 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈95.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 95.0 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q5T3F8 |
| Note | Gene ID: 55362; UniProt: Q5T3F8; Chromosome: 6p21.1; Predicted MW: 95.0 kDa |
| Function | Mechanosensitive cation channel with low conductance and high activation threshold. Osmosensitive cation channel preferentially activated by hypotonic stress. Also acts as a phospholipid scramblase in response to changes in membrane structure: upon changes in membrane curvature and thickness, alters its conformation and translocates phospholipids, such as phosphatidylcholine and sphingomyelin, thereby controlling plasma membrane lipid distribution. Forms a heterodimer with SLC19A2, which mediates phospholipid scramblase activity following Ca(2+) stimulation (By similarity). Expressed in excitatory neurons of the subfornical organ and functions as a thirst receptor that mediates neuronal response to hyperosmolality to drive thirst and drinking behavior (By similarity). Facilitates intestinal motility by promoting proliferation of intestinal stem cells (By similarity). Essential for the baby's first breath and respiration throughout life. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TMEM63B Polyclonal Antibody |
| Target | TMEM63B |
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