Rabbit Anti-SCNBA/SCN11A Polyclonal Antibody
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产品编号
PAV3600
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别名
sodium voltage-gated channel alpha subunit 11, FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sodium voltage-gated channel alpha subunit 11, FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2 |
| Catalog Number | PAV3600 |
| Product Description | Rabbit polyclonal antibody raised against human SCN11A (Sodium channel protein type 11 subunit alpha). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCN11A |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017] |
| Immunogen | This antibody was raised against from part region of human SCN11A protein (UniProt: Q9UI33) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 11280 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈204.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 204.9 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q9UI33 |
| Note | Gene ID: 11280; UniProt: Q9UI33; Chromosome: 3p22.2; Predicted MW: 204.9 kDa |
| Function | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCN11A Polyclonal Antibody |
| Target | SCN11A |
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