Rabbit Anti-SCNAA/SCNN1A Polyclonal Antibody
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产品编号
PAV3599
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别名
sodium channel epithelial 1 subunit alpha, BESC2, ENaCa, ENaCalpha, LIDLS3, PHA1B1, SCNEA, SCNN1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sodium channel epithelial 1 subunit alpha, BESC2, ENaCa, ENaCalpha, LIDLS3, PHA1B1, SCNEA, SCNN1 |
| Catalog Number | PAV3599 |
| Product Description | Rabbit polyclonal antibody raised against human SCNN1A (Epithelial sodium channel subunit alpha channel subunit alpha)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCNN1A |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009] |
| Immunogen | This antibody was raised against from part region of human SCNN1A protein (UniProt: P37088) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6337 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈75.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 75.7 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | P37088 |
| Note | Gene ID: 6337; UniProt: P37088; Chromosome: 12p13.31; Predicted MW: 75.7 kDa |
| Function | This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.; FUNCTION: [Isoform 4]: Not functional. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCNN1A Polyclonal Antibody |
| Target | SCNN1A |
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