Rabbit Anti-SCN8A Polyclonal Antibody
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产品编号
PAV3598
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别名
sodium voltage-gated channel alpha subunit 8, BFIS5, CERIII, CIAT, DEE13, EIEE13, MED, MYOCL2, NaCh6
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sodium voltage-gated channel alpha subunit 8, BFIS5, CERIII, CIAT, DEE13, EIEE13, MED, MYOCL2, NaCh6 |
| Catalog Number | PAV3598 |
| Product Description | Rabbit polyclonal antibody raised against human SCN8A (Sodium channel protein type 8 subunit alpha). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCN8A |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Immunogen | This antibody was raised against from part region of human SCN8A protein (UniProt: Q9UQD0) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6334 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈225.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 225.3 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q9UQD0 |
| Note | Gene ID: 6334; UniProt: Q9UQD0; Chromosome: 12q13.13; Predicted MW: 225.3 kDa |
| Function | Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation.; FUNCTION: [Isoform 5]: More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCN8A Polyclonal Antibody |
| Target | SCN8A |
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