Rabbit Anti-SCN1B Polyclonal Antibody

产品编号

PAV3596

别名

sodium voltage-gated channel beta subunit 1, ATFB13, BRGDA5, DEE52, EIEE52, GEFSP1

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	sodium voltage-gated channel beta subunit 1, ATFB13, BRGDA5, DEE52, EIEE52, GEFSP1
Catalog Number	PAV3596
Product Description	Rabbit polyclonal antibody raised against human SCN1B (Sodium channel regulatory subunit beta-1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	SCN1B
Species	Human, Rat, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	离子通道
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Immunogen	This antibody was raised against from part region of human SCN1B protein (UniProt: Q07699)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	6324
Tag	Unconjugated
Cross-reactivity	Human, Rat, Mouse
Predicted Molecular Weight	≈24.7 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	24.7 kDa
Cross-reactivity	Human, Rat, Mouse
Uniprot ID	Q07699
Note	Gene ID: 6324; UniProt: Q07699; Chromosome: 19q13.11; Predicted MW: 24.7 kDa
Function	Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8.; FUNCTION: [Isoform 2]: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth. Has no regulatory function on the SCN2A sodium channel complex.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human SCN1B Polyclonal Antibody
Target	SCN1B