Rabbit Anti-SCN1A Polyclonal Antibody
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产品编号
PAV3595
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别名
sodium voltage-gated channel alpha subunit 1, DEE6, DEE6A, DEE6B, DRVT, EIEE6, FEB3, FEB3A, FHM3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sodium voltage-gated channel alpha subunit 1, DEE6, DEE6A, DEE6B, DRVT, EIEE6, FEB3, FEB3A, FHM3 |
| Catalog Number | PAV3595 |
| Product Description | Rabbit polyclonal antibody raised against human SCN1A (Sodium channel protein type 1 subunit alpha). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCN1A |
| Species | H, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript. [provided by RefSeq, Oct 2015] |
| Immunogen | This antibody was raised against from part region of human SCN1A protein (UniProt: P35498) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6323 |
| Tag | Unconjugated |
| Cross-reactivity | H, Rat |
| Predicted Molecular Weight | ≈229.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 229.0 kDa |
| Cross-reactivity | H, Rat |
| Uniprot ID | P35498 |
| Note | Gene ID: 6323; UniProt: P35498; Chromosome: 2q24.3; Predicted MW: 229.0 kDa |
| Function | Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits (By similarity). Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCN1A Polyclonal Antibody |
| Target | SCN1A |
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