Rabbit Anti-NAC3/SCN3A Polyclonal Antibody
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产品编号
PAV2448
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别名
sodium voltage-gated channel alpha subunit 3, DEE62, EIEE62, FFEVF4, NAC3, Nav1.3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sodium voltage-gated channel alpha subunit 3, DEE62, EIEE62, FFEVF4, NAC3, Nav1.3 |
| Catalog Number | PAV2448 |
| Product Description | Rabbit polyclonal antibody raised against human SCN3A (Sodium channel protein type 3 subunit alpha). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCN3A |
| Species | Human, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human SCN3A protein (UniProt: Q9NY46) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6328 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat |
| Predicted Molecular Weight | ≈226.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 226.3 kDa |
| Cross-reactivity | Human, Rat |
| Uniprot ID | Q9NY46 |
| Note | Gene ID: 6328; UniProt: Q9NY46; Chromosome: 2q24.3; Predicted MW: 226.3 kDa |
| Function | Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCN3A Polyclonal Antibody |
| Target | SCN3A |
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