Rabbit Anti-NAC2/SCN2A Polyclonal Antibody
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产品编号
PAV2447
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别名
sodium voltage-gated channel alpha subunit 2, BFIC3, BFIS3, BFNIS, DEE11, EA9, EIEE11, HBA, HBSCI
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sodium voltage-gated channel alpha subunit 2, BFIC3, BFIS3, BFNIS, DEE11, EA9, EIEE11, HBA, HBSCI |
| Catalog Number | PAV2447 |
| Product Description | Rabbit polyclonal antibody raised against human SCN2A (Sodium channel protein type 2 subunit alpha). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCN2A |
| Species | Human, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 离子通道 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
| Immunogen | This antibody was raised against from part region of human SCN2A protein (UniProt: Q99250) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 6326 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat |
| Predicted Molecular Weight | ≈228.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 228.0 kDa |
| Cross-reactivity | Human, Rat |
| Uniprot ID | Q99250 |
| Note | Gene ID: 6326; UniProt: Q99250; Chromosome: 2q24.3; Predicted MW: 228.0 kDa |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCN2A Polyclonal Antibody |
| Target | SCN2A |
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