Rabbit Anti-RGMC/HJV Polyclonal Antibody
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产品编号
PAV3345
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别名
hemojuvelin BMP co-receptor, HFE2, HFE2A, JH, RGMC
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | hemojuvelin BMP co-receptor, HFE2, HFE2A, JH, RGMC |
| Catalog Number | PAV3345 |
| Product Description | Rabbit polyclonal antibody raised against human HJV (Hemojuvelin). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | HJV |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 激素与结合蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015] |
| Immunogen | This antibody was raised against from part region of human HJV protein (UniProt: Q6ZVN8) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 148738 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈45.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 45.1 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | Q6ZVN8 |
| Note | Gene ID: 148738; UniProt: Q6ZVN8; Chromosome: 1q21.1; Predicted MW: 45.1 kDa |
| Function | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human HJV Polyclonal Antibody |
| Target | HJV |
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