Rabbit Anti-PSYR/GPR65 Polyclonal Antibody
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产品编号
PAV3191
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别名
G protein-coupled receptor 65, TDAG8, hTDAG8
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | G protein-coupled receptor 65, TDAG8, hTDAG8 |
| Catalog Number | PAV3191 |
| Product Description | Rabbit polyclonal antibody raised against human GPR65 (G protein-coupled receptor 65). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | GPR65 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | G蛋白偶联受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables G protein-coupled receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to acidic pH; and positive regulation of stress fiber assembly. Is active in early endosome membrane; late endosome membrane; and plasma membrane. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human GPR65 protein (UniProt: Q8IYL9) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 8477 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈39.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 39.3 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q8IYL9 |
| Note | Gene ID: 8477; UniProt: Q8IYL9; Chromosome: 14q31.3; Predicted MW: 39.3 kDa |
| Function | Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 7.4. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR65 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also act as a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and regulating T-cell metabolism. Acts as a regulator of inflammation by mediating pH-sensing of extracellular acidification which takes place in inflamed tissues: activation regulates endo-lysosomal function of immune cells and T-cell metabolism (By similarity). Constitutively active in endosomes and stimulates adenylate cyclase production from endosomes independently from extracellular pH changes. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human GPR65 Polyclonal Antibody |
| Target | GPR65 |
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