Rabbit Anti-OPSB/OPN1SW Polyclonal Antibody
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产品编号
PAV2736
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别名
opsin 1, short wave sensitive, BCP, BOP, CBT
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | opsin 1, short wave sensitive, BCP, BOP, CBT |
| Catalog Number | PAV2736 |
| Product Description | Rabbit polyclonal antibody raised against human OPN1SW (Short-wave-sensitive opsin 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | OPN1SW |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | G蛋白偶联受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human OPN1SW protein (UniProt: P03999) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 611 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈38.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 38.7 kDa |
| Cross-reactivity | Human |
| Uniprot ID | P03999 |
| Note | Gene ID: 611; UniProt: P03999; Chromosome: 7q32.1; Predicted MW: 38.7 kDa |
| Function | G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to short-wavelength (blue-violet) light, thereby stimulating the G(t)/transducin protein pathway. This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels (By similarity). The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of cone photoreceptor function (By similarity). Involved in ensuring the correct abundance and localization of retinal membrane proteins (By similarity). Mediates visual perception of blue light. May contribute to increased spectral sensitivity under dim light conditions (By similarity). Is not UV-sensitive (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human OPN1SW Polyclonal Antibody |
| Target | OPN1SW |
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