Rabbit Anti-MRGX2/MRGPRX2 Polyclonal Antibody
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产品编号
PAV2363
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别名
MAS related GPR family member X2, MGRG3, MRGX2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | MAS related GPR family member X2, MGRG3, MRGX2 |
| Catalog Number | PAV2363 |
| Product Description | Rabbit polyclonal antibody raised against human MRGPRX2 (Mas-related G protein-coupled receptor member X2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MRGPRX2 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | G蛋白偶联受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human MRGPRX2 protein (UniProt: Q96LB1) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 117194 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈37.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 37.1 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q96LB1 |
| Note | Gene ID: 117194; UniProt: Q96LB1; Chromosome: 11p15.1; Predicted MW: 37.1 kDa |
| Function | Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions. A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells. Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. MRGPRX2 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MRGPRX2 Polyclonal Antibody |
| Target | MRGPRX2 |
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