Rabbit Anti-MRGRD/MRGPRD Polyclonal Antibody
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产品编号
PAV2362
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别名
MAS related GPR family member D, MRGD, TGR7
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | MAS related GPR family member D, MRGD, TGR7 |
| Catalog Number | PAV2362 |
| Product Description | Rabbit polyclonal antibody raised against human MRGPRD (Mas-related G protein-coupled receptor member D). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MRGPRD |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | G蛋白偶联受体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Located in obsolete extracellular space. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human MRGPRD protein (UniProt: Q8TDS7) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 116512 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈36.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 36.1 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q8TDS7 |
| Note | Gene ID: 116512; UniProt: Q8TDS7; Chromosome: 11q13.3; Predicted MW: 36.1 kDa |
| Function | G protein-coupled receptor that acts as a mediator of peripheral pain and itch sensations. Activated by various ligands, such as beta-alanine, beta-aminoisobutyrate, angiotensin 1-7, alamandine and allantoin, causing a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. MRGPRD is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity. MRGPRD is specifically expressed in neurons that innervate the epidermis and acts as a key mediator of skin stimuli, such as itch, pain and mechanical stimuli (By similarity). Required to maintain skin homeostasis in response to irritant dermatitis by initiating a signaling that promotes glutamate release, inhibiting mast cell hyperresponsiveness and skin inflammation (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MRGPRD Polyclonal Antibody |
| Target | MRGPRD |
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