Rabbit Anti-SMRCD/SMARCAD1 Polyclonal Antibody

产品编号

PAV3726

别名

SNF2 related chromatin remodeling ATPase with DExD box 1, ADERM, BASNS, ETL1, HEL1, HPGDS-AS1, HRZ, TYS

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	SNF2 related chromatin remodeling ATPase with DExD box 1, ADERM, BASNS, ETL1, HEL1, HPGDS-AS1, HRZ, TYS
Catalog Number	PAV3726
Product Description	Rabbit polyclonal antibody raised against human SMARCAD1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	SMARCAD1
Species	Human
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	表观修饰酶
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Immunogen	This antibody was raised against from part region of human SMARCAD1 protein (UniProt: Q9H4L7)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	56916
Tag	Unconjugated
Cross-reactivity	Human
Predicted Molecular Weight	≈117.4 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	117.4 kDa
Cross-reactivity	Human
Uniprot ID	Q9H4L7
Note	Gene ID: 56916; UniProt: Q9H4L7; Chromosome: 4q22.3; Predicted MW: 117.4 kDa
Function	Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human SMARCAD1 Polyclonal Antibody
Target	SMARCAD1