Rabbit Anti-SMAL1/SMARCAL1 Polyclonal Antibody
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产品编号
PAV3716
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别名
SNF2 related chromatin remodeling annealing helicase 1, HARP, HHARP
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SNF2 related chromatin remodeling annealing helicase 1, HARP, HHARP |
| Catalog Number | PAV3716 |
| Product Description | Rabbit polyclonal antibody raised against human SMARCAL1 (SNF2 related chromatin remodeling annealing helicase 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SMARCAL1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 表观修饰酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human SMARCAL1 protein (UniProt: Q9NZC9) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 50485 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈105.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 105.9 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q9NZC9 |
| Note | Gene ID: 50485; UniProt: Q9NZC9; Chromosome: 2q35; Predicted MW: 105.9 kDa |
| Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SMARCAL1 Polyclonal Antibody |
| Target | SMARCAL1 |
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