Rabbit Anti-SETB2/SETDB2 Polyclonal Antibody
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产品编号
PAV3630
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别名
SET domain bifurcated histone lysine methyltransferase 2, C13orf4, CLLD8, CLLL8, KMT1F
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SET domain bifurcated histone lysine methyltransferase 2, C13orf4, CLLD8, CLLL8, KMT1F |
| Catalog Number | PAV3630 |
| Product Description | Rabbit polyclonal antibody raised against human SETDB2 (Histone-lysine N-methyltransferase SETDB2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SETDB2 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 表观修饰酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| Immunogen | This antibody was raised against from part region of human SETDB2 protein (UniProt: Q96T68) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 83852 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈81.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 81.9 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q96T68 |
| Note | Gene ID: 83852; UniProt: Q96T68; Chromosome: 13q14.2; Predicted MW: 81.9 kDa |
| Function | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SETDB2 Polyclonal Antibody |
| Target | SETDB2 |
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