Rabbit Anti-NSUN2 Polyclonal Antibody
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产品编号
PAV2613
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别名
NOP2/Sun RNA methyltransferase 2, MISU, MRT5, SAKI, TRM4
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | NOP2/Sun RNA methyltransferase 2, MISU, MRT5, SAKI, TRM4 |
| Catalog Number | PAV2613 |
| Product Description | Rabbit polyclonal antibody raised against human NSUN2 (RNA cytosine C-methyltransferase NSUN2-methyltransferase)-methyltransferase)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NSUN2 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 表观修饰酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011] |
| Immunogen | This antibody was raised against from part region of human NSUN2 protein (UniProt: Q08J23) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 54888 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈86.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 86.5 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q08J23 |
| Note | Gene ID: 54888; UniProt: Q08J23; Chromosome: 5p15.31; Predicted MW: 86.5 kDa |
| Function | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NSUN2 Polyclonal Antibody |
| Target | NSUN2 |
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