Rabbit Anti-MXI1 Polyclonal Antibody
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产品编号
PAV2399
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别名
MAX interactor 1, dimerization protein, MAD2, MXD2, MXI, bHLHc11
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | MAX interactor 1, dimerization protein, MAD2, MXD2, MXI, bHLHc11 |
| Catalog Number | PAV2399 |
| Product Description | Rabbit polyclonal antibody raised against human MXI1 (Max-interacting protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MXI1 |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 表观修饰酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human MXI1 protein (UniProt: P50539) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 4601 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈26.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 26.1 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | P50539 |
| Note | Gene ID: 4601; UniProt: P50539; Chromosome: 10q25.2; Predicted MW: 26.1 kDa |
| Function | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MXI1 Polyclonal Antibody |
| Target | MXI1 |
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