Rabbit Anti-TOPB1/HELB Polyclonal Antibody
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产品编号
PAV4096
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别名
DNA helicase B, DHB, hDHB
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | DNA helicase B, DHB, hDHB |
| Catalog Number | PAV4096 |
| Product Description | Rabbit polyclonal antibody raised against human HELB (DNA helicase B). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | HELB |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | DNA损伤修复 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
| Immunogen | This antibody was raised against from part region of human HELB protein (UniProt: Q8NG08) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 92797 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈123.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 123.3 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q8NG08 |
| Note | Gene ID: 92797; UniProt: Q8NG08; Chromosome: 12q; Predicted MW: 123.3 kDa |
| Function | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human HELB Polyclonal Antibody |
| Target | HELB |
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