Rabbit Anti-SWAP1/SWSAP1 Polyclonal Antibody
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产品编号
PAV3883
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别名
SWIM-type zinc finger 7 associated protein 1, C19orf39, SWS1AP1, ZSWIM7AP1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SWIM-type zinc finger 7 associated protein 1, C19orf39, SWS1AP1, ZSWIM7AP1 |
| Catalog Number | PAV3883 |
| Product Description | Rabbit polyclonal antibody raised against human SWSAP1 (ATPase SWSAP1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SWSAP1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | DNA损伤修复 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables ATP hydrolysis activity and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination and protein stabilization. Part of Shu complex. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human SWSAP1 protein (UniProt: Q6NVH7) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 126074 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈26.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 26.6 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q6NVH7 |
| Note | Gene ID: 126074; UniProt: Q6NVH7; Chromosome: 19p13.2; Predicted MW: 26.6 kDa |
| Function | Single-stranded DNA-stimulated ATPase involved in DNA double-strand break (DSB) repair via homologous recombination (HR). Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA. The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments (By similarity). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid. Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly. Has a DNA-binding activity which is independent of its ATPase activity: preferentially binds DNA with an exposed 5' end. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SWSAP1 Polyclonal Antibody |
| Target | SWSAP1 |
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