Rabbit Anti-SMC1B Polyclonal Antibody
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产品编号
PAV3718
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别名
structural maintenance of chromosomes 1B, SMC1BETA, SMC1L2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | structural maintenance of chromosomes 1B, SMC1BETA, SMC1L2 |
| Catalog Number | PAV3718 |
| Product Description | Rabbit polyclonal antibody raised against human SMC1B (Structural maintenance of chromosomes protein 1B). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SMC1B |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | DNA损伤修复 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008] |
| Immunogen | This antibody was raised against from part region of human SMC1B protein (UniProt: Q8NDV3) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 27127 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈143.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 143.8 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q8NDV3 |
| Note | Gene ID: 27127; UniProt: Q8NDV3; Chromosome: 22q13.31; Predicted MW: 143.8 kDa |
| Function | Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SMC1B Polyclonal Antibody |
| Target | SMC1B |
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