Rabbit Anti-PAR12/PARP12 Polyclonal Antibody
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产品编号
PAV2929
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别名
poly(ADP-ribose) polymerase family member 12, ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | poly(ADP-ribose) polymerase family member 12, ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1 |
| Catalog Number | PAV2929 |
| Product Description | Rabbit polyclonal antibody raised against human PARP12 (Protein mono-ADP-ribosyltransferase PARP12). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PARP12 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | DNA损伤修复 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation and transepithelial transport. Is active in trans-Golgi network. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human PARP12 protein (UniProt: Q9H0J9) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 64761 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈79.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 79.1 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9H0J9 |
| Note | Gene ID: 64761; UniProt: Q9H0J9; Chromosome: 7q34; Predicted MW: 79.1 kDa |
| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication. Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4. Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1. Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by up-regulating ISG15 and ISGylation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PARP12 Polyclonal Antibody |
| Target | PARP12 |
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